You can exclude gain from the future sale of your main home (within the limits of the exclusion) as long as you satisfy the ownership and use requirements and haven't excluded gain from the sale of another home within the two-year period ending on the date of the sale. Also, if the future sale of your home is due to a change in employment, health, or unforeseen circumstances, you may qualify for a reduced exclusion even if you fail to meet the ownership and use requirements or you used the exclusion within the two-year period ending on the date of the sale. There's no limit to the number of times you can claim the exclusion.