Generally, no.  A loss on the sale or exchange of personal use property, including a capital loss on the sale of your home used by you as your personal residence at the time of sale, or loss attributable to the sale of part of your home that is used for personal purposes, isn't deductible. The only deductible losses associated with property (or a portion of property) are losses on property used in a trade or business, losses resulting from a transaction entered into for profit (for example, a loss on the sale of stock), and certain casualty losses. From taxable years 2018 through 2025, the only deductible casualty losses are those resulting from Federally declared disasters. Starting taxable year 2026, casualty losses resulting from state declared disasters are also deductible.